EVIDENCE THAT THE AMYGDALA IS INVOLVED IN THE INHIBITORY EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON ALCOHOL-DRINKING IN RATS

被引：31

作者：

DYR, W ^{[1
]}

KOSTOWSKI, W ^{[1
]}

机构：

[1] INST PSYCHIAT & NEUROL, DEPT PHARMACOL & PHYSIOL NERVOUS SYST, PL-02957 WARSAW, POLAND

来源：

ALCOHOL | 1995年 / 12卷 / 04期

关键词：

5HT(3) RECEPTOR AND ETHANOL; 5-HT3; ANTAGONISTS; ETHANOL DRINKING; ONDANSETRON; TROPISETRON; AMYGDALA; RAT;

D O I：

10.1016/0741-8329(95)00023-K

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Two 5-HT3 receptor antagonists, tropisetron (1 and 10 ng) and ondansetron (10 and 100 ng) were tested for effects on ethanol drinking in Wistar male rats after bilateral microinjection into the amygdala. The animals had limited access (2 h/day) to the 10% (v/v) ethanol solution, food and water were available ad lib during the scheduled access period. Both drugs caused a decrease in ethanol drinking. Tropisetron (1 and 10 ng) decreased ethanol intake during the first hour of access. The lower dose (10 ng) of ondansetron was more effective than the higher (100 ng) dose. The finding implicates amygdaloid 5-HT3 receptors in the mechanism of ethanol intake in Wistar rats.

引用

页码：387 / 391

页数：5

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