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BEHAVIORAL PHARMACOLOGY OF 5-HT3-RECEPTOR LIGANDS

被引：62
作者：
BARNES, JM [1 ]
BARNES, NM [1 ]
COOPER, SJ [1 ]
机构：
[1] UNIV BIRMINGHAM, SCH PSYCHOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1992年 / 16卷 / 01期
关键词：
5-HT3-RECEPTOR; PSYCHOSIS; ANXIETY; DRUGS OF ABUSE; COGNITION; APPETITE; SOCIAL ENCOUNTERS;
D O I：
10.1016/S0149-7634(05)80057-0
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Extensive studies have ascribed a role for the central 5-HT3 receptor in the modulation of behaviour. Much of the work stems from the actions of potent and selective 5-HT3 receptor antagonists; these agents reduce mesolimbic dopamine initiated hyperactivity, release suppressed behaviour, reduce the reinforcing properties and withdrawal symptoms of drugs of abuse, enhance cognitive performance and modulate appetite. This article reviews the preclinical and clinical evidence implicating the 5-HT3 receptor in these indications and discusses the potential neurochemical mechanisms underlying the behavioural changes.
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收藏
页码：107 / 113
页数：7
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