THE IMMUNE-RESPONSE TO HERPES-SIMPLEX VIRUS

被引：53

作者：

NASH, AA

CAMBOUROPOULOS, P

机构：

[1] Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, Tennis Court Road

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 03期

关键词：

HERPESVIRUS; NATURAL RESISTANCE; IMMUNOPATHOLOGY; CD4; T-CELLS; ANTIVIRAL ANTIBODIES;

D O I：

10.1006/smvy.1993.1013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several host immune mechanisms are activated in the course of a herpes simplex virus infection. These include natural resistance mechanisms (natural killer cells and interferon), antiviral antibodies and effector CD4 and CD8 T lymphocytes. An important mechanism in the control of viral replication in epidermal cells involves the recruitment and activation of macrophages by CD4 T cells. In some instances, the action of CD4 T cells can lead to immune pathology following infection of the eye (stromal ketatitis) or central nervous system (demyelination). Despite the efficiency of the immune response in countering infection, the virus has evolved strategies to subvert the action of antibodies and complement and the detection of infected cells by cytotoxic T lymphocytes. © 1993 Academic Press. All rights reserved.

引用

页码：181 / 186

页数：6

共 41 条

[11] ROLE OF INTERFERON IN PATHOGENESIS OF VIRUS DISEASES IN MICE AS DEMONSTRATED BY USE OF ANTI-INTERFERON SERUM .2. STUDIES WITH HERPES-SIMPLEX, MOLONEY SARCOMA, VESICULAR STOMATITIS, NEWCASTLE-DISEASE, AND INFLUENZA-VIRUSES [J].