Combined microbial oxidation and reduction: A new approach to the high-yield synthesis of homochiral unsaturated secondary alcohols from racemates

被引：42

作者：

Fantin, G ^{[1
]}

Fogagnolo, M ^{[1
]}

Giovannini, PP ^{[1
]}

Medici, A ^{[1
]}

Pedrini, P ^{[1
]}

机构：

[1] UNIV FERRARA,DIPARTMENTO CHIM,I-44100 FERRARA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 12期

关键词：

microbial oxidation; microbial reduction; Bacillus stearothermophilus; Yarrowia lipolytica; unsaturated secondary R-alcohol;

D O I：

10.1016/0957-4166(95)00402-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The oxidation of racemic secondary alcohols with Bacillus stearothermophilus followed by reduction of the mixture with Yarrowia lipolytica to afford high yields of the enantiomerically pure R-alcohols la,b,d is described. Comparisons with Yarrowia lipolytica reduction, Bacillus stearothermophilus oxidation, and the contemporary use of the two microrganisms have been made.

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页码：3047 / 3053

页数：7

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