ZARZISSINE, A NEW CYTOTOXIC GUANIDINE ALKALOID FROM THE MEDITERRANEAN SPONGE ANCHINOE-PAUPERTAS

被引：38

作者：

BOUAICHA, N

AMADE, P

PUEL, D

ROUSSAKIS, C

机构：

[1] UNIV NICE,FAC SCI,PHYSIOL CELLULAIRE & COMPAREE LAB,F-06108 NICE 2,FRANCE

[2] INST SCI & ORGANISMES MER,GRP SMAB,F-44035 NANTES 01,FRANCE

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 10期

关键词：

D O I：

10.1021/np50112a019

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From a CH2Cl2 extract of the Mediterranean sponge Anchinoe paupertas were isolated and characterized zarzissine [2], a new 4,5-guanidino-pyridazine compound and the known p-hydroxybenzaldehyde [1]. The structure of zarzissine [2] was elucidated by spectroscopic methods, including the application of a number of 2D nmr techniques. Biological activities of compounds 1 and 2 were also determined, with zarzissine exhibiting cytotoxicity against three human and murine turner cell lines.

引用

页码：1455 / 1457

页数：3

共 18 条

[1] ISOLATION, STRUCTURAL IDENTIFICATION AND BIOLOGICAL-ACTIVITY OF 2 METABOLITES PRODUCED BY PENICILLIUM-OLSONII BAINIER AND SARTORY [J].

AMADE, P ;

MALLEA, M ;

BOUAICHA, N .

JOURNAL OF ANTIBIOTICS, 1994, 47 (02) :201-207

[2] AUTOTOXIC ANTIBIOTIC PRODUCTION BY A MARINE CHROMOBACTERIUM [J].

ANDERSEN, RJ ;

WOLFE, MS ;

FAULKNER, DJ .

MARINE BIOLOGY, 1974, 27 (04) :281-285

[3]

Baker JT, 1976, HDB MARINE SCI COMPO, VI, P50

[4] CRAMBINE-C1 AND CRAMBINE-C2 - 2 FURTHER ICHTHYOTOXIC GUANIDINE ALKALOIDS FROM THE SPONGE CRAMBE-CRAMBE [J].

BERLINCK, RGS ;

BRAEKMAN, JC ;

DALOZE, D ;

BRUNO, I ;

RICCIO, R ;

ROGEAU, D ;

AMADE, P .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (04) :528-532

[5] BIOACTIVE DITERPENOIDS ISOLATED FROM DILOPHUS-LIGULATUS [J].

BOUAICHA, N ;

TRINGALI, C ;

PESANDO, D ;

MALLEA, M ;

ROUSSAKIS, C ;

VERBIST, JF .

PLANTA MEDICA, 1993, 59 (03) :256-258

[6] CYTOTOXIC DITERPENOIDS FROM THE BROWN ALGA DILOPHUS-LIGULATUS [J].

BOUAICHA, N ;

PESANDO, D ;

PUEL, D .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (10) :1747-1752

[7]

CHEVOLOT L, 1981, MARINE NATURAL PRODU, V4, P53

[8] A NATURALLY-OCCURRING ANALOG OF METHYLTHIOADENOSINE (MTA) FROM THE NUDIBRANCH MOLLUSK DORIS-VERRUCOSA [J].

CIMINO, G ;

CRISPINO, A ;

DESTEFANO, S ;

GAVAGNIN, M ;

SODANO, G .

EXPERIENTIA, 1986, 42 (11-12) :1301-1302

[9] ISOLATION AND X-RAY CRYSTAL-STRUCTURE OF A NOVEL 8-OXOPURINE COMPOUND FROM A MARINE SPONGE [J].

CIMINO, G ;

DEGIULIO, A ;

DEROSA, S ;

DESTEFANO, S ;

PULITI, R ;

MATTIA, CA ;

MAZZARELLA, L .

JOURNAL OF NATURAL PRODUCTS, 1985, 48 (04) :523-528

[10]

COURVALIN P, 1985, ANTIBIOGRAMME, P22

← 1 2 →