SYNTHESIS OF THE 2,3-EPOXY-2,3-DIHYDRO-2,3-DIMETHYLBENZO[B]FURAN, THE PROPOSED ULTIMATE MUTAGEN OF THE BENZOFURAN DIOXETANES

被引：25

作者：

ADAM, W ^{[1
]}

HADJIARAPOGLOU, L ^{[1
]}

MOSANDL, T ^{[1
]}

SAHAMOLLER, CR ^{[1
]}

WILD, D ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHARMACOL & TOXIKOL,W-8700 WURZBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 02期

关键词：

D O I：

10.1002/anie.199102001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dioxetanes can be precursors for mutagenic epoxides-this provocative hypothesis is the result of this study. Epoxidation of the benzofurans 1 with dimethyldioxirane and deoxygenation of the benzofuran dioxetanes 3 with dimethyl sulfides allows for the first time the synthesis of libile furanepoxides 2. Compounds 2 and 3 are strongly mutagenic in the histidine-auxotrophic Salmonella typhimurium strain TA 100. X = H, Ac.

引用

页码：200 / 202

页数：3

共 21 条

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