EARLY ACTIVATION OF PBMC AND APPEARANCE OF ANTIVIRAL CD8+ CELLS INFLUENCE THE PROGNOSIS OF SIV-INDUCED DISEASE IN RHESUS MACAQUES

被引：31

作者：

JOAG, SV

ADAMS, RJ

FORESMAN, L

GALBREATH, D

ZINK, MC

PINSON, DM

MCCLURE, H

NARAYAN, O

机构：

[1] EMORY UNIV,YERKES REG PRIMATE RES CTR,ATLANTA,GA 30322

[2] JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

SIV; AIDS; T-LYMPHOCYTE; CELL-MEDIATED IMMUNITY; VIRUS PATHOGENESIS; LYMPHOCYTE ACTIVATION;

D O I：

10.1111/j.1600-0684.1994.tb00110.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from mitogen-stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy.

引用

页码：108 / 116

页数：9

共 18 条

[1] HIV REVEALED - TOWARD A NATURAL-HISTORY OF THE INFECTION
BALTIMORE, D
FEINBERG, MB
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) : 1673 - 1675
[2] CHUANG RY, 1993, ADV BIOSCI, V68, P573
[3] HIGH TITERS OF CYTOPATHIC VIRUS IN PLASMA OF PATIENTS WITH SYMPTOMATIC PRIMARY HIV-1 INFECTION
CLARK, SJ
SAAG, MS
DECKER, WD
CAMPBELLHILL, S
ROBERSON, JL
VELDKAMP, PJ
KAPPES, JC
HAHN, BH
SHAW, GM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (14) : 954 - 960
[4] TRANSIENT HIGH-LEVELS OF VIREMIA IN PATIENTS WITH PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
DAAR, ES
MOUDGIL, T
MEYER, RD
HO, DD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (14) : 961 - 964
[5] THE SIMIAN IMMUNODEFICIENCY VIRUSES
DESROSIERS, RC
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 : 557 - 578
[6] ANTIGENIC VARIATION OF MOLECULARLY CLONED SIV(MAC)239 DURING PERSISTENT INFECTION IN A RHESUS MACAQUE
JOAG, SV
ANDERSON, MG
CLEMENTS, JE
MCENTEE, MF
SHARMA, DP
ADAMS, RJ
NARAYAN, O
[J]. VIROLOGY, 1993, 195 (02) : 406 - 412
[7] JOAG SV, IN PRESS VIROLOGY
[8] KANNAGI M, 1988, J IMMUNOL, V140, P2237
[9] Lennette EH, 1969, DIAGNOSTIC PROCEDURE, P1
[10] RINGLER DJ, 1990, LAB INVEST, V62, P435

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