METHODOLOGY FOR THE TESTING OF FOOD DYES FOR GENOTOXIC ACTIVITY - EXPERIMENTS WITH RED 2G (CI-18050)

被引：15

作者：

HAVELANDSMITH, RB ^{[1
]}

COMBES, RD ^{[1
]}

BRIDGES, BA ^{[1
]}

机构：

[1] UNIV SUSSEX,MRC,CELL MUTAT UNIT,BRIGHTON BN1 9QG,E SUSSEX,ENGLAND

来源：

MUTATION RESEARCH | 1979年 / 64卷 / 04期

关键词：

D O I：

10.1016/0165-1161(79)90093-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A methodology for investigating genotoxicity of food colours using the fluctuation and DNA-repair assays with bacteria is described. In addition, a liquid repair test, developed to permit incorporation of microsomes and the quantitative estimation of cell viability, has been characterised with a number of positive control agents. Results obtained in these systems suggest that the food colour Red 2G induces repairable DNA damage and base-substitution mutation, but only in the presence of a rat-liver microsomal preparation. The significance of the data in the light of other toxicological information is discussed. © 1979.

引用

页码：241 / 248

页数：8

共 26 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].

AMES, BN ;

MCCANN, J ;

YAMASAKI, E .

MUTATION RESEARCH, 1975, 31 (06) :347-363

[2] LACK OF MUTAGENIC ACTIVITY OF A SERIES OF FOOD DYES FOR SALMONELLA-TYPHIMURIUM [J].

AULETTA, AE ;

KUZAVA, JM ;

PARMAR, AS .

MUTATION RESEARCH, 1977, 56 (02) :203-206

[3] MUTAGENICITY TESTING OF CERTIFIED FOOD COLORS AND RELATED AZO, XANTHENE AND TRIPHENYLMETHANE DYES WITH SALMONELLA-MICROSOME SYSTEM [J].

BROWN, JP ;

ROEHM, GW ;

BROWN, RJ .

MUTATION RESEARCH, 1978, 56 (03) :249-271

[4] FOOD COLORS - HARMLESS AESTHETICS OR EPICUREAN LUXURIES [J].

DRAKE, JJP .

TOXICOLOGY, 1975, 5 (01) :3-42

[5] QUANTITATIVE MICROSOMAL MUTAGENESIS ASSAY METHOD [J].

FRANTZ, CN ;

MALLING, HV .

MUTATION RESEARCH, 1975, 31 (06) :365-379

[6]

GARNER RC, 1977, MUTAT RES, V44, P9

[7] MUTAGEN TESTING USING TRP+ REVERSION IN ESCHERICHIA-COLI [J].

GREEN, MHL ;

MURIEL, WJ .

MUTATION RESEARCH, 1976, 38 (01) :3-32

[8] USE OF A SIMPLIFIED FLUCTUATION TEST TO DETECT LOW-LEVELS OF MUTAGENS [J].

GREEN, MHL ;

MURIEL, WJ ;

BRIDGES, BA .

MUTATION RESEARCH, 1976, 38 (01) :33-41

[9] MUTAGEN SCREENING BY A SIMPLIFIED BACTERIAL FLUCTUATION TEST - USE OF MICROSOMAL PREPARATIONS AND WHOLE LIVER-CELLS FOR METABOLIC ACTIVATION [J].

GREEN, MHL ;

BRIDGES, BA ;

ROGERS, AM ;

HORSPOOL, G ;

MURIEL, WJ ;

BRIDGES, JW ;

FRY, JR .

MUTATION RESEARCH, 1977, 48 (3-4) :287-293

[10] IN-VITRO AND HOST-MEDIATED REC-ASSAY PROCEDURES FOR SCREENING CHEMICAL MUTAGENS - AND PHLOXINE, A MUTAGENIC RED DYE DETECTED [J].

KADA, T ;

TUTIKAWA, K ;

SADAIE, Y .

MUTATION RESEARCH, 1972, 16 (02) :165-&

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