ONLINE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC GAS-CHROMATOGRAPHIC TANDEM ION TRAP MASS-SPECTROMETRIC DETERMINATION OF LEVAMISOLE IN MILK

被引：19

作者：

CHAPPELL, CG

CREASER, CS

STYGALL, JW

SHEPHERD, MJ

机构：

[1] UNIV E ANGLIA, SCH CHEM SCI, NORWICH NR4 7TJ, NORFOLK, ENGLAND

[2] MAFF, FOOD SCI LAB, NORWICH NR4 7UQ, ENGLAND

来源：

BIOLOGICAL MASS SPECTROMETRY | 1992年 / 21卷 / 12期

关键词：

D O I：

10.1002/bms.1200211211

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

On-line high-performance liquid chromatography/high-resolution gas chromatography/tandem mass spectrometry, performed on a quadrupole ion trap, has been used as a rapid method for the quantification of the anthelmintic drug levamisole in raw milk extracts following a simple extraction procedure. Detection at the 0.5 pp.b. level and a linear response in the 10-0.5 p.p.b. range is demonstrated. Multiple-scan monitoring techniques have been used to acquire chemical ionization tandem mass spectra and electron impact mass spectra in a single chromatographic run.

引用

页码：688 / 692

页数：5

共 16 条

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