PLASMAPHERESIS IN ACUTE EPISODES OF FULMINANT CNS INFLAMMATORY DEMYELINATION

被引：88

作者：

RODRIGUEZ, M ^{[1
]}

KARNES, WE ^{[1
]}

BARTLESON, JD ^{[1
]}

PINEDA, AA ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,TRANSFUS MED SECT,ROCHESTER,MN 55905

来源：

NEUROLOGY | 1993年 / 43卷 / 06期

关键词：

D O I：

10.1212/WNL.43.6.1100

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.

引用

页码：1100 / 1104

页数：5

共 24 条

[1] QUANTITATIVE MRI CHANGES IN GADOLINIUM-DTPA ENHANCEMENT AFTER HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN MULTIPLE-SCLEROSIS [J].

BARKHOF, F ;

HOMMES, OR ;

SCHELTENS, P ;

VALK, J .

NEUROLOGY, 1991, 41 (08) :1219-1222

[2] INTRAVENOUS METHYLPREDNISOLONE FOR MULTIPLE-SCLEROSIS IN RELAPSE [J].

BARNES, MP ;

BATEMAN, DE ;

CLELAND, PG ;

DICK, DJ ;

WALLS, TJ ;

NEWMAN, PK ;

SAUNDERS, M ;

TILLEY, PJB .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1985, 48 (02) :157-159

[3] TREATMENT OF ACUTE EXACERBATIONS OF MULTIPLE-SCLEROSIS WITH INTRAVENOUS METHYLPREDNISOLONE [J].

BUCKLEY, C ;

KENNARD, C ;

SWASH, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1982, 45 (02) :179-180

[4] THE EFFECT OF HIGH-DOSE STEROIDS ON MRI GADOLINIUM ENHANCEMENT IN ACUTE DEMYELINATING LESIONS [J].

BURNHAM, JA ;

WRIGHT, RR ;

DREISBACH, J ;

MURRAY, RS .

NEUROLOGY, 1991, 41 (09) :1349-1354

[5]

Dau P C, 1991, J Clin Apher, V6, P200, DOI 10.1002/jca.2920060405

[6] PLASMAPHERESIS IN MULTIPLE-SCLEROSIS - PRELIMINARY FINDINGS [J].

DAU, PC ;

PETAJAN, JH ;

JOHNSON, KP ;

PANITCH, HS ;

BORNSTEIN, MB .

NEUROLOGY, 1980, 30 (10) :1023-1028

[7] HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN THE TREATMENT OF MULTIPLE-SCLEROSIS - CLINICAL-IMMUNOLOGICAL CORRELATIONS [J].

DURELLI, L ;

COCITO, D ;

RICCIO, A ;

BARILE, C ;

BERGAMASCO, B ;

BAGGIO, GF ;

PERLA, F ;

DELSEDIME, M ;

GUSMAROLI, G ;

BERGAMINI, L .

NEUROLOGY, 1986, 36 (02) :238-243

[8]

KHATRI BO, 1988, NEUROLOGY, V38, P50

[9] PLASMA-EXCHANGE IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS - A LONG-TERM STUDY [J].

KHATRI, BO ;

MCQUILLEN, MP ;

HOFFMANN, RG ;

HARRINGTON, GJ ;

SCHMOLL, D .

NEUROLOGY, 1991, 41 (03) :409-414

[10] CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS - DOUBLE-BLIND CONTROLLED-STUDY OF PLASMAPHERESIS IN PATIENTS TAKING IMMUNOSUPPRESSIVE DRUGS [J].

KHATRI, BO ;

MCQUILLEN, MP ;

HARRINGTON, GJ ;

SCHMOLL, D ;

HOFFMANN, RG .

NEUROLOGY, 1985, 35 (03) :312-319

← 1 2 3 →