BIOACTIVE FURANONAPHTHOQUINONES FROM CRESCENTIA-CUJETE

被引:58
作者
HELTZEL, CE
GUNATILAKA, AAL
GLASS, TE
KINGSTON, DGI
HOFFMANN, G
JOHNSON, RK
机构
[1] VIRGINIA POLYTECH INST & STATE UNIV, DEPT CHEM, BLACKSBURG, VA 24061 USA
[2] SMITHKLINE BEECHAM PHARMACEUT, RES & DEV, KING OF PRUSSIA, PA 19406 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 09期
关键词
D O I
10.1021/np50099a008
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioassay-directed fractionation of the MeCOEt extract of Crescentia cujete (Bignonaceae) resulted in the isolation of (2S,3S)-3-hydroxy-5,6-dimethoxydehydroiso-alpha-lapachone [1], (2R)-5,6-dimethoxydehydroiso-alpha-lapachone [2],(2R)-5-methoxydehydroiso-alpha-lapachone [3], 2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione [4], 5-hydroxy-2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione [5],2-isopropenylnaphtho[2,3-b]furan-4,9-dione [6], and 5-hydroxydehydroiso-alpha-lapachone [7]. Compounds 1-3 are new, and all compounds are bioactive, showing selective activity towards DNA-repair-deficient yeast mutants. The isolation, structure elucidation, and biological activities of these compounds are reported.
引用
收藏
页码:1500 / 1505
页数:6
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