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LEISHMANIA-INFANTUM TROPISM - STRAIN GENOTYPE OR HOST IMMUNE STATUS

被引：94
作者：
GRADONI, L
GRAMICCIA, M
机构：
[1] Luigi Gradoni and Marina Gromiccia are, the Laboratorio di Parossitologia, Istituto Superiore di Sanitá, 00161 Rome
来源：
PARASITOLOGY TODAY | 1994年 / 10卷 / 07期
关键词：
D O I：
10.1016/0169-4758(94)90142-2
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
In apparently immunocompetent patients, Leishmania infantum provokes a spectrum of disease, ranging from simple skin lesion to severe visceral leishmaniasis, that is determined mainly by the protozoan genotype. In HIV-positive individuals, leishmanial infection results almost exclusively in visceral disease. In this review, Luigi Gradoni and Marina Gramiccia discuss the role of the intrinsic virulence of L. infantum strains and the immune condition of the host and focus on recently described mechanisms of immunological control of leishmanial infection.
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页码：264 / 267
页数：4
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