THERMOANALYTICAL AND SPECTRAL STUDY OF BENZODIAZEPINS .1. LORAZEPAM

被引：3

作者：

KADOURA, J

CHAUVET, A

TEROL, A

MASSE, J

机构：

来源：

THERMOCHIMICA ACTA | 1991年 / 179卷

关键词：

D O I：

10.1016/0040-6031(91)80335-G

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Thermoanalytical and spectral studies have been performed on commercial lorazepam (a) and its solvates obtained after recrystallisation at 20-degrees-C in methanol (b), propanol (c), ethyl acetate (d) and chloroform (e). The solvates' stoichiometry has been determined by thermogravimetry to be b, 3-2; c, 1-1, d, 3-1, and e, 3-2 and confirmed by nuclear magnetic resonance for b, c, and e. Their melting points (degrees-C), measured by differential scanning calorimetry, are b, 176.1 +/- 0.5; c, 178.9 +/- 0.8; d, 183.0 +/- 0.6; and e, 178.9 +/- 0.6). These differ from the value for a (183.1 +/- 0.6), confirming lorazepam polymorphism.

引用

页码：61 / 79

页数：19

共 18 条

[11]

Herman A. S., 1963, INFRARED HDB

[12]

Kuhnert-Brandstatter M., 1974, SCI PHARM, V42, P234

[13] APPLICATION OF DIFFERENTIAL CALORIMETRIC ANALYSIS TO DETERMINATION OF PURITY OF ORGANIC-DRUGS [J].