HUMAN DOPAMINE TRANSPORTER GENE (DAT1) MAPS TO CHROMOSOME-5P15.3 AND DISPLAYS A VNTR

被引：567

作者：

VANDENBERGH, DJ

PERSICO, AM

HAWKINS, AL

GRIFFIN, CA

LI, X

JABS, EW

UHL, GR

机构：

[1] NIDA,ADDICT RES CTR,MOLEC NEUROBIOL LAB,POB 5180,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL NEUROSCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,CTR ONCOL,BALTIMORE,MD 21205

来源：

GENOMICS | 1992年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0888-7543(05)80138-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans. © 1992 Academic Press, Inc. All rights reserved.

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页码：1104 / 1106

页数：3

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