THE PRESENCE OF ISLET AMYLOID POLYPEPTIDE/CALCITONIN GENE-RELATED PEPTIDE/SALMON CALCITONIN BINDING-SITES IN THE RAT NUCLEUS-ACCUMBENS

被引：25

作者：

VEALE, PR ^{[1
]}

BHOGAL, R ^{[1
]}

MORGAN, DGA ^{[1
]}

SMITH, DM ^{[1
]}

BLOOM, SR ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,LONDON W12 0NN,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期

关键词：

IAPP (ISLET AMYLOID POLYPEPTIDE); CGRP (CALCITONIN GENE-RELATED PEPTIDE); SALMON CALCITONIN; NUCLEUS ACCUMBENS;

D O I：

10.1016/0014-2999(94)90036-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Receptor autoradiographic analysis of binding in rat brain sections for [I-125]islet amyloid polypeptide (IAPP), [I-125]calcitonin gene-related peptide (CGRP) and [I-125]salmon calcitonin indicated dense binding for all three ligands in the nucleus accumbens. Membrane binding studies revealed the existence of high affinity sites for all three peptides. The order of potency of various related peptides at each binding site was investigated and found for [I-125]IApp to be salmon calcitonin > IAPP = alpha CGRP > salmon calcitonin-(8-32); for [I-125]CGRP to be alpha CGRP > IAPP > salmon calcitonin; and for [I-125]salmon calcitonin to be salmon calcitonin > alpha CGRP > rat calcitonin > salmon calcitonin-(8-32) > IAPP, suggesting that [I-125]IAPP targets the CGRP(3) receptor subtype. This study confirms the existence of two receptors in the rat nucleus accumbens binding salmon calcitonin, one of which binds (alpha CGRP and IAPP with a high affinity.

引用

页码：133 / 141

页数：9

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