ABSENCE OF IN-SITU HYBRIDIZATION EVIDENCE FOR LATENT-PHASE OR LYTIC-PHASE EPSTEIN-BARR-VIRUS INFECTION OF PREINVASIVE SQUAMOUS LESIONS OF THE CERVIX

被引：21

作者：

PAYNE, S

KERNOHAN, NM

WALKER, F

机构：

[1] Department of Pathology, University of Aberdeen, Aberdeen, AB9 2ZD, University Medical Buildings, Foresterhill

来源：

JOURNAL OF PATHOLOGY | 1995年 / 176卷 / 03期

关键词：

EPSTEIN-BARR VIRUS; CERVIX; HUMAN PAPILLOMAVIRUS; IN SITU HYBRIDIZATION; CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN);

D O I：

10.1002/path.1711760303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate whether Epstein-Barr virus (EBV) infection of the uterine cervix plays a significant role in cervical carcinogenesis, 30 preinvasive squamous lesions were subjected to in situ hybridization for (EBER-1,-2, and BHLF1) EBV transcripts which are expressed in latent and lytic infection, respectively. Twenty cases were known to contain EBV sequences by previous polymerase chain reaction (PCR) analysis. Irrespective of EBV PCR status or histological grade, none of the 30 cases demonstrated EBV transcripts in squamous epithelial cells. Two cases showed very occasional EBER-positive stromal cells, most probably representing resident cervical lymphocytes. These findings suggest that EBV plays no part in early cervical carcinogenesis.

引用

页码：221 / 226

页数：6

共 40 条

[1]

BROUSSET P, 1993, BLOOD, V3, P872

[2] EPSTEIN-BARR-VIRUS IN CARCINOMA OF THE VULVA [J].

CHEUNG, ANY ;

KHOO, US ;

KWONG, KY ;

SRIVASTAVA, G ;

COLLINS, RJ .

JOURNAL OF CLINICAL PATHOLOGY, 1993, 46 (09) :849-851

[3] CLONAL P53 MUTATION IN PRIMARY CERVICAL-CANCER - ASSOCIATION WITH HUMAN-PAPILLOMAVIRUS-NEGATIVE TUMORS [J].

CROOK, T ;

WREDE, D ;

TIDY, JA ;

MASON, WP ;

EVANS, DJ ;

VOUSDEN, KH .

LANCET, 1992, 339 (8801) :1070-1073

[4] HERPES-SIMPLEX VIRUS AND HUMAN PAPILLOMAVIRUS SITES CORRELATE WITH CHROMOSOMAL BREAKPOINTS IN HUMAN CERVICAL-CARCINOMA [J].

DEBRAEKELEER, M ;

SREEKANTAIAH, C ;

HAAS, O .

CANCER GENETICS AND CYTOGENETICS, 1992, 59 (02) :135-137

[5]

GILLIGAN K, 1990, P NATL ACAD SCI USA, V87, P870

[6] REPLICATION OF EPSTEIN-BARR VIRUS WITHIN THE EPITHELIAL-CELLS OF ORAL HAIRY LEUKOPLANKIA, AN AIDS-ASSOCIATED LESION [J].

GREENSPAN, JS ;

GREENSPAN, D ;

LENNETTE, ET ;

ABRAMS, DI ;

CONANT, MA ;

PETERSEN, V ;

FREESE, UK .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (25) :1564-1571

[7] GENETIC ALTERATIONS OF THE TP53 GENE, P53 PROTEIN EXPRESSION AND HPV INFECTION IN PRIMARY CERVICAL CARCINOMAS [J].

HELLAND, A ;

HOLM, R ;

KRISTENSEN, G ;

KAERN, J ;

KARLSEN, F ;

TROPE, C ;

NESLAND, JM ;

BORRESEN, AL .

JOURNAL OF PATHOLOGY, 1993, 171 (02) :105-114

[8]

HERBST H, 1992, BLOOD, V2, P484

[9]

HILTON DA, 1993, CANCER, V72, P1946, DOI 10.1002/1097-0142(19930915)72:6<1946::AID-CNCR2820720625>3.0.CO

[10]

2-7

← 1 2 3 4 →