IMMUNIZATION OF WOODCHUCKS WITH RECOMBINANT HEPATITIS DELTA-ANTIGEN DOES NOT PROTECT AGAINST HEPATITIS DELTA VIRUS-INFECTION

被引：25

作者：

KARAYIANNIS, P

SALDANHA, J

MONJARDINO, J

GOLDIN, R

MAIN, J

LUTHER, S

EASTON, M

PONZETTO, A

THOMAS, HC

机构：

[1] ST MARYS HOSP,SCH MED,IMPERIAL COLL SCI TECHNOL & MED,DEPT PATHOL,LONDON W2 1NY,ENGLAND

[2] OSPED MOLINETTE,DIV GASTROENTEROL,TURIN,ITALY

来源：

HEPATOLOGY | 1990年 / 12卷 / 05期

关键词：

D O I：

10.1002/hep.1840120508

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To assess the role of immunization against hepatitis delta antigen in the prevention of hepatitis delta virus infection, woodchuck carriers of woodchuck hepatitis virus were immunized with a 64 amino acid portion of hepatitis delta antigen from its N‐terminal region. The protein was expressed in Escherichia coli and contained a major immunogenic epitope. A significant anti‐hepatitis delta response was observed that did not, however, protect the animals from hepatitis delta virus superinfection. Unexpectedly, the period of detectable viremia was longer in the immunized than in the control animals. We conclude that immunization with this recombinant hepatitis delta antigen does not afford protection against subsequent hepatitis delta virus exposure. (HEPATOLOGY 1990;12:1125–1128). Copyright © 1990 American Association for the Study of Liver Diseases

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页码：1125 / 1128

页数：4

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