GENOTOXIC POTENTIAL OF CROWN ETHERS IN MAMMALIAN-CELLS - INDUCTION OF SISTER-CHROMATID EXCHANGES

被引：17

作者：

ARENAZ, P ^{[1
]}

BITTICKS, I ^{[1
]}

PANNELL, KH ^{[1
]}

GARCIA, S ^{[1
]}

机构：

[1] UNIV TEXAS,DEPT CHEM,EL PASO,TX 79968

来源：

MUTATION RESEARCH | 1992年 / 280卷 / 02期

关键词：

CROWN ETHERS; SISTER-CHROMATID EXCHANGES; IONOPHORES; POLYETHERS; MACROCYCLIC;

D O I：

10.1016/0165-1218(92)90006-L

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Crown ethers are macrocyclic polyethers which possess ionophoric properties. These compounds are currently being studied for potential use as pharmaceutical agents as well as antibacterials. Though crown ethers have been shown to be highly toxic in prokaryotes and eukaryotes, there have been few investigations into the potential genotoxicity of these compounds. When sister-chromatid exchanges (SCEs) were quantitated after exposure to crown ethers, the results reflected no significant genotoxic effects on Chinese hamster V79 cells at any of the crown ether concentrations utilized. One crown ether, dicyclohexyl 21-crown-7, did appear to possess antigenotoxic activity. The data on the induction of SCEs by crown ethers reported herein suggest that these compounds are not genotoxic in mammalian cells despite their cytotoxicity.

引用

页码：109 / 115

页数：7

共 19 条

[1] GENOTOXIC POTENTIAL OF CROWN ETHERS IN SALMONELLA-TYPHIMURIUM [J].