PHOTOSENSITIZATION WITH DERIVATIVES OF CHLORIN P(6)

被引：38

作者：

KESSEL, D

WOODBURN, K

GOMER, CJ

JAGEROVIC, N

SMITH, KM

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT MED,DETROIT,MI 48201

[2] CHILDRENS HOSP LOS ANGELES,DEPT ONCOL,LOS ANGELES,CA 90027

[3] UNIV SO CALIF,LOS ANGELES,CA 90027

[4] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1995年 / 28卷 / 01期

关键词：

PHOTOSENSITIZATION; CHLORINS; PHOTODYNAMIC THERAPY;

D O I：

10.1016/1011-1344(94)07085-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biophysical and photobiological properties of three derivatives of chlorin p(6) were examined. These agents can be considered as lysyl analogs of the aspartyl chlorin NPe6. Lysyl chlorin p(6) diester (LCP) and the triester analog (LCP2) were readily accumulated by murine leukemia L1210 cells, localized in lysosomes, and were relatively inefficient photosensitizing agents in vitro. In contrast, lysyl chlorin e(6) imide (LCI) was poorly accumulated, concentrated in mitochondrial and plasma membranes, but was more efficacious. LCI was the most effective agent with regard to photosensitization of a murine tumor in vivo, but ail three agents caused substantially more toxicity than was observed with NPe6.

引用

页码：13 / 18

页数：6

共 24 条

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