HUMAN GENE FOR BETA-MICROSEMINOPROTEIN - ITS PROMOTER STRUCTURE AND CHROMOSOMAL LOCALIZATION

被引：22

作者：

OCHIAI, Y

INAZAWA, J

UEYAMA, H

OHKUBO, I

机构：

[1] SHIGA UNIV MED SCI, DEPT MED BIOCHEM, OTSU, SHIGA 52021, JAPAN

[2] KYOTO PREFECTURAL UNIV MED, DEPT HYG, KAMIKYO KU, KYOTO 602, JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1995年 / 117卷 / 02期

关键词：

CHROMOSOMAL LOCALIZATION; GENE STRUCTURE; HUMAN SEMINAL PLASMA; BETA-MICROSEMINOPROTEIN; TRANSIENT EXPRESSION ASSAY;

D O I：

10.1093/jb/117.2.346

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene for human beta-microseminoprotein (MSP, beta-inhibin, prostatic secretory protein(94), or PSP94) was isolated. The nucleotide sequence of its upstream region (2,860 bp), exon 1 (35 bp), and a part of the following intron (218 bp) was determined. Transient transfection analysis on MSP-expressing (PC-3) and -nonexpressing (HepG2) cells using luciferase reporter plasmids suggested that the region from -2738 to -276 is not essential for the basal promoter activity, and that the regions from -275 to -207 and from -186 to -128 function in a cell-specific manner. The chromosome locus of the gene (MSMB) was determined through application of PCR to the DNAs of rodent-human somatic cell hybrids and also by the fluorescence in situ hybridization technique to be region q11.2 of chromosome 10.

引用

页码：346 / 352

页数：7

共 30 条

[1] CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE
ADEN, DP
FOGEL, A
PLOTKIN, S
DAMJANOV, I
KNOWLES, BB
[J]. NATURE, 1979, 282 (5739) : 615 - 616
[2] BETA-2-INHIBIN CONTAINS THE ACTIVE CORE OF HUMAN SEMINAL PLASMA BETA-INHIBIN - SYNTHESIS AND BIOACTIVITY
ARBATTI, NJ
SEIDAH, NG
ROCHEMONT, J
ESCHER, E
SHETH, AR
CHRETIEN, M
[J]. FEBS LETTERS, 1985, 181 (01) : 57 - 63
[3] ANALYSIS OF THE PROMOTER OF THE HUMAN PROSTATIC ACID-PHOSPHATASE GENE
BANAS, B
BLASCHKE, D
FITTLER, F
HORZ, W
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1217 (02): : 188 - 194
[4] SOURCES AND EVOLUTION OF HUMAN ALU REPEATED SEQUENCES
BRITTEN, RJ
BARON, WF
STOUT, DB
DAVIDSON, EH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) : 4770 - 4774
[5] THE T-CELL RECEPTOR BETA-CHAIN GENES ARE LOCATED ON CHROMOSOME-6 IN MICE AND CHROMOSOME-7 IN HUMANS
CACCIA, N
KRONENBERG, M
SAXE, D
HAARS, R
BRUNS, GAP
GOVERMAN, J
MALISSEN, M
WILLARD, H
YOSHIKAI, Y
SIMON, M
HOOD, L
MAK, TW
[J]. CELL, 1984, 37 (03) : 1091 - 1099
[6] HUMAN INHIBITOR OF THE 1ST COMPONENT OF COMPLEMENT, C1 - CHARACTERIZATION OF CDNA CLONES AND LOCALIZATION OF THE GENE TO CHROMOSOME-11
DAVIS, AE
WHITEHEAD, AS
HARRISON, RA
DAUPHINAIS, A
BRUNS, GAP
CICARDI, M
ROSEN, FS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) : 3161 - 3165
[7] HIGH FIDELITY DNA-SYNTHESIS BY THE THERMUS-AQUATICUS DNA-POLYMERASE
ECKERT, KA
KUNKEL, TA
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (13) : 3739 - 3744
[8] COMPILATION OF VERTEBRATE-ENCODED TRANSCRIPTION FACTORS
FAISST, S
MEYER, S
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (01) : 3 - 26
[9] A COMPARATIVE-STUDY ON EXPRESSION OF PROSTATIC INHIBIN PEPTIDE, PROSTATE ACID-PHOSPHATASE AND PROSTATE-SPECIFIC ANTIGEN IN ANDROGEN-INDEPENDENT HUMAN AND RAT PROSTATE CARCINOMA CELL-LINES
GARDE, SV
SHETH, AR
PORTER, AT
PIENTA, KJ
[J]. CANCER LETTERS, 1993, 70 (03) : 159 - 166
[10] CLONING AND NUCLEOTIDE-SEQUENCE ANALYSIS OF THE HUMAN BETA-MICROSEMINOPROTEIN GENE
GREEN, CB
LIU, WY
KWOK, SCM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (03) : 1184 - 1190

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