INTERFERENCE OF PLASMIC DEGRADATION PRODUCTS OF HUMAN CROSSLINKED FIBRIN WITH CLOT FORMATION

被引：28

作者：

BUDZYNSKI, AZ ^{[1
]}

OLEXA, SA ^{[1
]}

BRIZUELA, BS ^{[1
]}

机构：

[1] TEMPLE UNIV, HLTH SCI CTR, DEPT BIOCHEM, PHILADELPHIA, PA 19140 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 584卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Clot formation; Coagulation; Fibrin; Fibrinogen; Plasmic degradation product;

D O I：

10.1016/0304-4165(79)90273-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of plasmic degradation products of human crosslinked fibrin on polymerization of fibrin monomer and clot formation was studied. Both reactions were inhibited by Fragment DD, which formed a complex with fibrin monomer in a molar ratio 1 : 1. The rate of polymerization was slightly increased by Fragment E but it was not affected by (DD)E complex and Fragment A. Approximately the same amount of fibrin was formed in the presence and absence of Fragments A, E and the complex. It was concluded that of the degradation products of crosslinked fibrin, only Fragment DD is a potent anticoagulant at physiologic pH. The (DD)E complex is inert and Fragments A and E have only marginal effects. © 1979.

引用

页码：284 / 287

页数：4

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