ELEVATED ANTIBODIES TO SYNTHETIC PEPTIDES OF HTLV-1 ENVELOPE TRANSMEMBRANE GLYCOPROTEINS IN PATIENTS WITH HAM TSP

被引:21
作者
NAKAMURA, M
KUROKI, M
KIRA, J
ITOYAMA, Y
SHIRAKI, H
KURODA, N
WASHITANI, Y
NAKANO, S
NAGAFUCHI, S
ANZAI, K
TATSUMOTO, T
ESAKI, T
MAEDA, Y
NIHO, Y
机构
[1] FUKUOKA RED CROSS BLOOD CTR,FUKUOKA 818,JAPAN
[2] KYUSHU UNIV,INST NEUROL,DEPT NEUROL,FUKUOKA 812,JAPAN
关键词
HUMAN T LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1); HUMAN T LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) ASSOCIATED MYELOPATHY (HAM); TROPICAL SPASTIC PARAPARESIS (TSP); ELEVATED ANTIBODY TO HTLV-1 ENVELOPE TRANSMEMBRANE GLYCOPROTEIN;
D O I
10.1016/0165-5728(91)90171-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We studied the antibody response to various kinds of well-characterized synthetic peptides of human T lymphotropic virus type 1 (HTLV-1) envelope glycoproteins in patients with HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and non-HAM/TSP HTLV-1 carriers. The serum antibody titers to most of the synthetic peptides were significantly higher in patients with HAM/TSP than those in non-HAM/TSP HTLV-1 carriers. However, the degree of the increase of antibody titers to the synthetic peptides corresponding to the transmembrane portions of HTLV-1 envelope glycoproteins (env-p20E), such as p20E 332-352, 374-392, 426-448 and 458-488, was greater than those to synthetic peptides of exterior portions of HTLV-1 envelope glycoproteins (env-gp46) in sera from patients with HAM/TSP. Antibodies to env-p20E 332-352 and 374-392 were elevated in the cerebrospinal fluid (CSF) only from patients with HAM/TSP but not from non-HAM/TSP HTLV-1 carriers. These data indicate that the increase of antibody titers to transmembrane portions of HTLV-1 envelope glycoproteins in sera and CSF is a characteristic feature of antibody response in patients with HAM/TSP and may be closely associated with the development of HAM/TSP from non-HAM/TSP HTLV-1 carriers.
引用
收藏
页码:167 / 177
页数:11
相关论文
共 33 条
  • [11] HTLV-I-ASSOCIATED MYELOPATHY - OLIGOCLONAL IMMUNOGLOBULIN-G BANDS CONTAIN ANTI-HTLV-I P24 ANTIBODY
    GRIMALDI, LME
    ROOS, RP
    DEVARE, SG
    CASEY, JM
    MARUO, Y
    HAMADA, T
    TASHIRO, K
    [J]. ANNALS OF NEUROLOGY, 1988, 24 (06) : 727 - 731
  • [12] ADULT T-CELL LEUKEMIA - ANTIGEN IN AN ATL CELL-LINE AND DETECTION OF ANTIBODIES TO THE ANTIGEN IN HUMAN-SERA
    HINUMA, Y
    NAGATA, K
    HANAOKA, M
    NAKAI, M
    MATSUMOTO, T
    KINOSHITA, KI
    SHIRAKAWA, S
    MIYOSHI, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10): : 6476 - 6480
  • [13] Hoop TP, 1985, P NATL ACAD SCI USA, V78, P3824
  • [14] SPONTANEOUS PROLIFERATION OF PERIPHERAL-BLOOD LYMPHOCYTES INCREASED IN PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY
    ITOYAMA, Y
    MINATO, S
    KIRA, J
    GOTO, I
    SATO, H
    OKOCHI, K
    YAMAMOTO, N
    [J]. NEUROLOGY, 1988, 38 (08) : 1302 - 1307
  • [15] ALTERED SUBSETS OF PERIPHERAL-BLOOD LYMPHOCYTES IN PATIENTS WITH HTLV-I ASSOCIATED MYELOPATHY (HAM)
    ITOYAMA, Y
    MINATO, S
    KIRA, J
    GOTO, I
    SATO, H
    OKOCHI, K
    YAMAMOTO, N
    [J]. NEUROLOGY, 1988, 38 (05) : 816 - 818
  • [16] IMMUNOLOGICAL STUDIES IN TROPICAL SPASTIC PARAPARESIS
    JACOBSON, S
    GUPTA, A
    MATTSON, D
    MINGIOLI, E
    MCFARLIN, DE
    [J]. ANNALS OF NEUROLOGY, 1990, 27 (02) : 149 - 156
  • [17] CIRCULATING CD8+ CYTOTOXIC LYMPHOCYTES-T SPECIFIC FOR HTLV-I PX IN PATIENTS WITH HTLV-I ASSOCIATED NEUROLOGICAL DISEASE
    JACOBSON, S
    SHIDA, H
    MCFARLIN, DE
    FAUCI, AS
    KOENIG, S
    [J]. NATURE, 1990, 348 (6298) : 245 - 248
  • [18] JACOBSON S, 1991, J IMMUNOL, V146, P1155
  • [19] INCREASED HTLV-I PROVIRAL DNA IN HTLV-I-ASSOCIATED MYELOPATHY - A QUANTITATIVE POLYMERASE CHAIN-REACTION STUDY
    KIRA, J
    KOYANAGI, Y
    YAMADA, T
    ITOYAMA, Y
    GOTO, I
    YAMAMOTO, N
    SASAKI, H
    SAKAKI, Y
    [J]. ANNALS OF NEUROLOGY, 1991, 29 (02) : 194 - 201
  • [20] DETECTION OF ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I BY USING SYNTHETIC PEPTIDES
    KURODA, N
    WASHITANI, Y
    SHIRAKI, H
    KIYOKAWA, H
    OHNO, M
    SATO, H
    MAEDA, Y
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (05) : 865 - 868