ON THE FREQUENCY OF METAPHASE CHROMOSOME-ABERRATIONS IN THE SMALL-INTESTINE OF AGED RATS

被引：3

作者：

ELLSWORTH, JL ^{[1
]}

SCHIMKE, RT ^{[1
]}

机构：

[1] STANFORD UNIV,DEPT BIOL SCI,STANFORD,CA 94305

来源：

JOURNALS OF GERONTOLOGY | 1990年 / 45卷 / 03期

关键词：

D O I：

10.1093/geronj/45.3.B94

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Abnormalities in DNA synthesis and cell proliferation are characteristic of aged populations of proliferating cells. Cytogenetic analysis of jejunal crypt cells from young and senescent rats indicate that the imbalance in cell production in vivo is associated with an age-dependent increase in metaphase chromosome aberrations. Furthermore, the frequency of these chromosome aberrations is correlated with histologic evidence of cell death. These results demonstrate that the maintenance of genomic integrity is distributed in the aged small intestine and may explain the age-related increase in the proportion of relatively undifferentiated villus epithelial cells in the small intestine of senescent rats.

引用

页码：B94 / B100

页数：7

共 69 条

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