DIONCOPHYLLINE-A, THE PRINCIPAL CYTOTOXIN FROM ANCISTROCLADUS-LETESTUI

被引：12

作者：

HALLOCK, YF ^{[1
]}

HUGHES, CB ^{[1
]}

CARDELLINA, JH ^{[1
]}

SCHAFFER, M ^{[1
]}

GULDEN, KP ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

NATURAL PRODUCT LETTERS | 1995年 / 6卷 / 04期

关键词：

DIONCOPHYLLINE A; NAPHTHYLISOQUINOLINE; ANCISTROCLADUS LETESTUI; CYTOTOXIN; OXIDATIVE DEGRADATION;

D O I：

10.1080/10575639508043177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using bioassay-guided fractionation, dioncophylline A [1] was isolated from the leaves and twigs of the tropical liana Ancistrocladus letestui Pelligr. Dioncophylline A was previously known from Triphyophyllum peltatum and A. abbreviatus. The in vitro cytotoxicity profile of 1 was characterized against the NCI panel of human tumor cell lines.

引用

页码：315 / 320

页数：6

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