THE CYP 2A GENE SUBFAMILY - SPECIES-DIFFERENCES, REGULATION, CATALYTIC ACTIVITIES AND ROLE IN CHEMICAL CARCINOGENESIS

被引：70

作者：

FERNANDEZSALGUERO, P ^{[1
]}

GONZALEZ, FJ ^{[1
]}

机构：

[1] NCI,BETHESDA,MD 20892

来源：

PHARMACOGENETICS | 1995年 / 5卷

关键词：

D O I：

10.1097/00008571-199512001-00013

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The CYP2A subfamily has been characterized in several mammalian species including mouse, rat, rabbit, hamster, cattle and human, Marked species differences have been demonstrated in the catalytic activities and regulation of this subfamily, In humans, the CYP2A genes are found as a cluster on the long arm of chromosome 19 with the CYP2B and CYP2F genes. Marked interindividual differences in expression of the CYP2A6 gene was found in livers analyzed in vitro and in humans phenotyped in vivo by using coumarin, a specific substrate for the enzyme. Efforts are underway to determine the existence of mutant and variant CYP2A6 alleles in the human population, Since CYP2A6 is able to metabolically-activate chemical carcinogens and is expressed in extrahepatic tissue, it will be of interest to determine whether genetic differences in expression of the gene is associated with cancer risk.

引用

页码：S123 / S128

页数：6

共 56 条

[41]

PENG HM, 1993, J BIOL CHEM, V268, P17253

[42] ISOLATION AND SEQUENCE OF A HUMAN CYTOCHROME-P-450 CDNA CLONE [J].

PHILLIPS, IR ;

SHEPHARD, EA ;

ASHWORTH, A ;

RABIN, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (04) :983-987

[43] IMMUNOCHEMICAL AND CATALYTICAL STUDIES ON HEPATIC COUMARIN 7-HYDROXYLASE IN MAN, RAT, AND MOUSE [J].

RAUNIO, H ;

SYNGELMA, T ;

PASANEN, M ;

JUVONEN, R ;

HONKAKOSKI, P ;

KAIRALUOMA, MA ;

SOTANIEMI, E ;

LANG, MA ;

PELKONEN, O .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (20) :3889-3895

[44]

RAUTIO A, 1992, PHARMACOGENETICS, V5, P227

[45]

SIMMONS DL, 1983, J BIOL CHEM, V258, P9585

[46]

SIMMONS DL, 1985, J BIOL CHEM, V266, P515

[47] GENETIC-REGULATION OF TESTOSTERONE 15 ALPHA-HYDROXYLASE (CYTOCHROME-P-45015-ALPHA) IN RENAL MICROSOMES OF FEMALE MICE [J].

SQUIRES, EJ ;

NEGISHI, M .

BIOCHEMISTRY, 1986, 25 (17) :4913-4918

[48]

SQUIRES EJ, 1988, J BIOL CHEM, V263, P4166

[49] THE AH-RECEPTOR - GENETICS, STRUCTURE AND FUNCTION [J].

SWANSON, HI ;

BRADFIELD, CA .

PHARMACOGENETICS, 1993, 3 (05) :213-230

[50]

UENO T, 1990, NUCLEIC ACIDS RES, V15, P4623

← 1 2 3 4 5 6 →