TISSUE CULTURE STUDIES OF SHEEP PULMONARY ADENOMATOSIS (JAAGSIEKTE) .2. TRANSMISSION OF CYTOPATHIC EFFECTS TO NORMAL CULTURES

被引:31
作者
MACKAY, JMK
机构
[1] Department of Microbiology, Moredun Research Institute, Edinburgh, Gilmerton
基金
英国惠康基金;
关键词
D O I
10.1016/0021-9975(69)90040-1
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Methods for the serial transmission of a viral cytopathic effect originating in direct cultures of jaagsiekte lung lesions are described. This effect appears to be restricted to macrophages. Cells of this type derived from the lesions of disease were used in the first instance as substrate. Alveolar macrophages from the lungs of apparently normal sheep have also been used and the effects are serially transmissible in this system with cell-free inocula. Some of the factors influencing the development of cytopathic effects have been investigated and the system has also been used to examine some of the characteristics of the virus responsible. Preliminary findings suggest that it may be a member of the herpes group. The aetiological significance of this agent in relation to jaagsiekte is unknown. © 1968.
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页码:147 / &
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