INHIBITORY EFFECTS OF FLAVONOIDS ON SEVERAL VENOM HYALURONIDASES

被引：69

作者：

KUPPUSAMY, UR

DAS, NP

机构：

[1] Laboratory of Flavonoid Research, Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore, 0511, Kent Ridge Crescent

来源：

EXPERIENTIA | 1991年 / 47卷 / 11-12期

关键词：

FLAVONOIDS-HYALURONIDASE INHIBITION-VENOM ACTION;

D O I：

10.1007/BF01918384

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In vitro studies showed that the flavonoid aglycones apigenin, luteolin and kaempferol inhibited the hyaluronidase activity of five different venoms dose-dependently. They were also able to delay the venom action when injected into mice. Naringenin, catechin and flavonoid glycosides had no effect. The flavonoids with unsubstituted hydroxyl groups at C-positions 5, 7 and 4', a double bond between carbons 2 and 3, as well as a ketone group at position 4, exhibited potent inhibitory actions on the venom hyaluronidases.

引用

页码：1196 / 1200

页数：5

共 23 条

[1]

Beretz A, 1986, Prog Clin Biol Res, V213, P281

[2] INVIVO SYNERGY OF CARDIOTOXIN AND PHOSPHOLIPASE-A2 FROM THE ELAPID SNAKE NAJA-MOSSAMBICA-MOSSAMBICA [J].

BOUGIS, PE ;

MARCHOT, P ;

ROCHAT, H .

TOXICON, 1987, 25 (04) :427-431

[3]

FERRELL JE, 1979, MOL PHARMACOL, V16, P556

[4] HYALURONIDASE POLYMORPHISM DETECTED BY POLYACRYLAMIDE-GEL ELECTROPHORESIS - APPLICATION TO HYALURONIDASES FROM BACTERIA, SLIME-MOLDS, BEE AND SNAKE-VENOMS, BOVINE TESTES, RAT-LIVER LYSOSOMES, AND HUMAN-SERUM [J].

FISZERSZAFARZ, B .

ANALYTICAL BIOCHEMISTRY, 1984, 143 (01) :76-81

[5]

Geissman TA, 1962, CHEM FLAVONOID COMPO, P1

[6] NEUTRALIZATION OF HYALURONIDASE AND INDIRECT HEMOLYTIC ACTIVITIES OF COSTA RICAN SNAKE-VENOMS BY A POLYVALENT ANTIVENOM [J].

GENE, JA ;

GOMEZ, M ;

GUTIERREZ, JM ;

CERDDAS, L .

TOXICON, 1985, 23 (06) :1015-1018

[7] BEE WASP VENOMS [J].

HABERMAN.E .

SCIENCE, 1972, 177 (4046) :314-+

[8]

Harborne J B, 1986, Prog Clin Biol Res, V213, P15

[9] FLAVONOIDS, A CLASS OF NATURAL-PRODUCTS OF HIGH PHARMACOLOGICAL POTENCY [J].

HAVSTEEN, B .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (07) :1141-1148

[10] INHIBITION OF THE MITOCHONDRIAL NADH-OXIDASE (NADH-COENZYME-Q OXIDOREDUCTASE) ENZYME-SYSTEM BY FLAVONOIDS - A STRUCTURE-ACTIVITY STUDY [J].

HODNICK, WF ;

BOHMONT, CW ;

CAPPS, C ;

PARDINI, RS .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (17) :2873-2874

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