INHIBITORY EFFECTS OF FLAVONOIDS ON SEVERAL VENOM HYALURONIDASES

被引：69

作者：

KUPPUSAMY, UR

DAS, NP

机构：

[1] Laboratory of Flavonoid Research, Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore, 0511, Kent Ridge Crescent

来源：

EXPERIENTIA | 1991年 / 47卷 / 11-12期

关键词：

FLAVONOIDS-HYALURONIDASE INHIBITION-VENOM ACTION;

D O I：

10.1007/BF01918384

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In vitro studies showed that the flavonoid aglycones apigenin, luteolin and kaempferol inhibited the hyaluronidase activity of five different venoms dose-dependently. They were also able to delay the venom action when injected into mice. Naringenin, catechin and flavonoid glycosides had no effect. The flavonoids with unsubstituted hydroxyl groups at C-positions 5, 7 and 4', a double bond between carbons 2 and 3, as well as a ketone group at position 4, exhibited potent inhibitory actions on the venom hyaluronidases.

引用

页码：1196 / 1200

页数：5

共 23 条

[21] CHARACTERIZATION OF LIZARD VENOM HYALURONIDASE AND EVIDENCE FOR ITS ACTION AS A SPREADING FACTOR [J].

TU, AT ;

HENDON, RR .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1983, 76 (02) :377-383

[22] COMPARISON OF THE EFFECTS OF VARIOUS FLAVONOIDS ON ETHOXYCOUMARIN DEETHYLASE ACTIVITY OF RAT INTESTINAL AND HEPATIC MICROSOMES [J].

VERNET, A ;

SIESS, MH .

FOOD AND CHEMICAL TOXICOLOGY, 1986, 24 (08) :857-861

[23] PURIFICATION AND PARTIAL CHARACTERIZATION OF HYALURONIDASE FROM 5 PACE SNAKE (AGKISTRODON-ACUTUS) VENOM [J].

XU, X ;

WANG, XS ;

XI, XT ;

LIU, J ;

HUANG, JT ;

LU, ZX .

TOXICON, 1982, 20 (06) :973-+

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