CDNA;
DAUNORUBICIN REDUCTASE;
QUINONE REDUCTASE;
DRUG METABOLISM;
D O I:
10.1016/0378-1119(94)00843-H
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Two cDNA sequences encoding rabbit carbonyl reductase (CBR) were cloned from a lambda gt10 rabbit liver cDNA library, The rabbit cDNAs coded for a protein with 84% identity to human CBR. Transient expression of the two rabbit cDNA sequences in COS7 cells increased both quinone reductase and aldo-keto reductase activities. These data demonstrate that CBR cDNAs from rabbit and human tissues code for similar proteins.