学术探索
学术期刊
新闻热点
数据分析
智能评审

NEUROTRANSMITTER-GATED ION CHANNELS AS UNCONVENTIONAL ALLOSTERIC PROTEINS

被引：191
作者：
GALZI, JL
CHANGEUX, JP
机构：
[1] Institut Pasteur, Neurobiologie Moléculaire, URA CNRS D1284, 75015 Paris
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(94)90218-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biochemical, mutagenesis and electron microscopy investigations of neurotransmitter receptors linked with ion channels result in a map of the neurotransmitter binding site and the ion channel at the amino acid level. The data are consistent with the view that these quasi-symmetrical hetero-oligomers are allosteric proteins, yet with distinctive features associated with their transmembrane disposition.
引用
收藏
页码：554 / 565
页数：12
相关论文
共 99 条
  • [21] A NEGATIVE CHARGE IN THE M2 TRANSMEMBRANE SEGMENT OF THE NEURONAL-ALPHA-7 ACETYLCHOLINE-RECEPTOR INCREASES PERMEABILITY TO DIVALENT-CATIONS
    FERRERMONTIEL, AV
    MONTAL, M
    [J]. FEBS LETTERS, 1993, 324 (02): : 185 - 190
  • [22] A POINT MUTATION IN A DROSOPHILA GABA RECEPTOR CONFERS INSECTICIDE RESISTANCE
    FFRENCHCONSTANT, RH
    ROCHELEAU, TA
    STEICHEN, JC
    CHALMERS, AE
    [J]. NATURE, 1993, 363 (6428) : 449 - 451
  • [23] REGIONS OF BETA-4.BETA-2 SUBUNIT CHIMERAS THAT CONTRIBUTE TO THE AGONIST SELECTIVITY OF NEURONAL NICOTINIC RECEPTORS
    FIGL, A
    COHEN, BN
    QUICK, MW
    DAVIDSON, N
    LESTER, HA
    [J]. FEBS LETTERS, 1992, 308 (03) : 245 - 248
  • [24] ALLOSTERIC TRANSITIONS OF THE ACETYLCHOLINE-RECEPTOR PROBED AT THE AMINO-ACID LEVEL WITH A PHOTOLABILE CHOLINERGIC LIGAND
    GALZI, JL
    REVAH, F
    BOUET, F
    MENEZ, A
    GOELDNER, M
    HIRTH, C
    CHANGEUX, JP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) : 5051 - 5055
  • [25] FUNCTIONAL-SIGNIFICANCE OF AROMATIC-AMINO-ACIDS FROM 3 PEPTIDE LOOPS OF THE ALPHA-7 NEURONAL NICOTINIC RECEPTOR-SITE INVESTIGATED BY SITE-DIRECTED MUTAGENESIS
    GALZI, JL
    BERTRAND, D
    DEVILLERSTHIERY, A
    REVAH, F
    BERTRAND, S
    CHANGEUX, JP
    [J]. FEBS LETTERS, 1991, 294 (03): : 198 - 202
  • [26] GALZI JL, 1990, J BIOL CHEM, V265, P10430
  • [27] MUTATIONS IN THE CHANNEL DOMAIN OF A NEURONAL NICOTINIC RECEPTOR CONVERT ION SELECTIVITY FROM CATIONIC TO ANIONIC
    GALZI, JL
    DEVILLERSTHIERY, A
    HUSSY, N
    BERTRAND, S
    CHANGEUX, JP
    BERTRAND, D
    [J]. NATURE, 1992, 359 (6395) : 500 - 505
  • [28] STRUCTURE OF THE HIGH-AFFINITY BINDING-SITE FOR NONCOMPETITIVE BLOCKERS OF THE ACETYLCHOLINE-RECEPTOR - SERINE-262 OF THE DELTA-SUBUNIT IS LABELED BY [H-3] CHLORPROMAZINE
    GIRAUDAT, J
    DENNIS, M
    HEIDMANN, T
    CHANG, JY
    CHANGEUX, JP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) : 2719 - 2723
  • [29] STRUCTURE OF THE HIGH-AFFINITY BINDING-SITE FOR NONCOMPETITIVE BLOCKERS OF THE ACETYLCHOLINE-RECEPTOR - (H-3) CHLORPROMAZINE LABELS HOMOLOGOUS RESIDUES IN THE BETA-CHAIN AND DELTA-CHAIN
    GIRAUDAT, J
    DENNIS, M
    HEIDMANN, T
    HAUMONT, PY
    LEDERER, F
    CHANGEUX, JP
    [J]. BIOCHEMISTRY, 1987, 26 (09) : 2410 - 2418
  • [30] THE TRANSMEMBRANE DOMAINS OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR CONTAIN ALPHA-HELICAL AND BETA-STRUCTURES
    GORNETSCHELNOKOW, U
    STRECKER, A
    KADUK, C
    NAUMANN, D
    HUCHO, F
    [J]. EMBO JOURNAL, 1994, 13 (02) : 338 - 341
12345678910