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STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF SYNTHETIC HYDRAZINES AS ECDYSONE AGONISTS IN THE CONTROL OF SPRUCE BUDWORM (CHORISTONEURA-FUMIFERANA)

被引：14
作者：
MOHAMMEDALI, AK
CHAN, TH
THOMAS, AW
STRUNZ, GM
JEWETT, B
机构：
[1] MCGILL UNIV, DEPT CHEM, MONTREAL, PQ H3A 2K6, CANADA
[2] CANADIAN FOREST SERV, FREDERICTON, NB E3B 5P7, CANADA
来源：
CANADIAN JOURNAL OF CHEMISTRY | 1995年 / 73卷 / 04期
关键词：
SPRUCE BUDWORM; ECDYSONE; AGONIST; HYDRAZINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;
D O I：
10.1139/v95-071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A quantitative structure-activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high pi value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone.
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页码：550 / 557
页数：8
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