EUDISTOMIDIN-B, EUDISTOMIDIN-C, AND EUDISTOMIDIN-D - NOVEL ANTILEUKEMIC ALKALOIDS FROM THE OKINAWAN MARINE TUNICATE EUDISTOMA-GLAUCUS

被引:111
作者
KOBAYASHI, J
CHENG, JF
OHTA, T
NOZOE, S
OHIZUMI, Y
SASAKI, T
机构
[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN
[2] KANAZAWA UNIV,CANC RES INST,KANAZAWA,ISHIKAWA 920,JAPAN
关键词
D O I
10.1021/jo00298a056
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Marine tunicates have proven to be a rich source of intriguing structures and interesting biological activities.2 In our continuing survey of bioactive compounds from Okinawan marine organisms,3 we have reported a novel β-carboline, named eudistomidin A (1), with powerful calmodulin antagonistic activity from the Okinawan tunicate Eudistoma glaucus4. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:3666 / 3670
页数:5
相关论文
共 27 条
[11]   IEJIMALIDE-A AND IEJIMALIDE-B, NOVEL 24-MEMBERED MACROLIDES WITH POTENT ANTILEUKEMIC ACTIVITY FROM THE OKINAWAN TUNICATE EUDISTOMA CF RIGIDA [J].
KOBAYASHI, J ;
CHENG, JF ;
OHTA, T ;
NAKAMURA, H ;
NOZOE, S ;
HIRATA, Y ;
OHIZUMI, Y ;
SASAKI, T .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (26) :6147-6150
[12]   AMPHIDINOLIDE-C - THE 1ST 25-MEMBERED MACROCYCLIC LACTONE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP [J].
KOBAYASHI, J ;
ISHIBASHI, M ;
WALCHLI, MR ;
NAKAMURA, H ;
HIRATA, Y ;
SASAKI, T ;
OHIZUMI, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (02) :490-494
[13]   CYSTODYTIN-A, CYSTODYTIN-B, AND CYSTODYTIN-C, NOVEL TETRACYCLIC AROMATIC ALKALOIDS WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE OKINAWAN TUNICATE CYSTODYTES-DELLECHIAJEI [J].
KOBAYASHI, J ;
CHENG, JF ;
WALCHLI, MR ;
NAKAMURA, H ;
HIRATA, Y ;
SASAKI, T ;
OHIZUMI, Y .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (08) :1800-1804
[14]   EUDISTOMIDIN-A, A NOVEL CALMODULIN ANTAGONIST FROM THE OKINAWAN TUNICATE EUDISTOMA-GLAUCUS [J].
KOBAYASHI, J ;
NAKAMURA, H ;
OHIZUMI, Y ;
HIRATA, Y .
TETRAHEDRON LETTERS, 1986, 27 (10) :1191-1194
[15]   EUDISTOMINS A, D, G, H, I, J, M, N, O, P, AND Q, BROMO-BETA-CARBOLINES HYDROXY-BETA-CARBOLINES PYRROLYL-BETA-CARBOLINES AND 1-PYRROLINYL-BETA-CARBOLINES FROM THE ANTIVIRAL CARIBBEAN TUNICATE EUDISTOMA-OLIVACEUM [J].
KOBAYASHI, J ;
HARBOUR, GC ;
GILMORE, J ;
RINEHART, KL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) :1526-1528
[16]  
KOBAYASHI M, 1989, JPN J PHARMACOL, V49, P278
[17]   EUDISTOMIN-K SULFOXIDE - AN ANTIVIRAL SULFOXIDE FROM THE NEW-ZEALAND ASCIDIAN RITTERELLA-SIGILLINOIDES [J].
LAKE, RJ ;
BRENNAN, MM ;
BLUNT, JW ;
MUNRO, MHG ;
PANNELL, LK .
TETRAHEDRON LETTERS, 1988, 29 (18) :2255-2256
[18]  
MULLER L, 1979, J AM CHEM SOC, V101, P4481
[19]  
NAKAMURA Y, 1986, J BIOL CHEM, V261, P4139
[20]   A SERIES OF CHIRAL POLYBROMINATED BIINDOLES FROM THE MARINE BLUE-GREEN-ALGA RIVULARIA-FIRMA - APPLICATION OF C-13 NMR SPIN-LATTICE RELAXATION DATA AND C-13-H-1 COUPLING-CONSTANTS TO STRUCTURE ELUCIDATION [J].
NORTON, RS ;
WELLS, RJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (13) :3628-3635