The process of saturable-gain degenerate four-wave mixing in a diode-pumped microchip Nd:YVO4 amplifier is investigated. To enhance the efficiency of the interaction, multipass geometries are employed in which the weak signal beam and therefore the conjugate beam experience several passes in the gain medium. Degenerate four-wave mixing reflectivities as high as R = 10% and R = 170% have been obtained experimentally for 130-W diode pumping with two-pass and four-pass geometries, respectively. Finally, the imaging capabilities of the volume population hologram written in the Nd:YVO4 amplifier are demonstrated.