RESISTANCE OF MICE DEFICIENT IN IL-4 TO RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME (MAIDS)

被引：110

作者：

KANAGAWA, O ^{[1
]}

VAUPEL, BA ^{[1
]}

GAYAMA, S ^{[1
]}

KOEHLER, G ^{[1
]}

KOPF, M ^{[1
]}

机构：

[1] MAX PLANCK INST IMMUNBIOL,W-7800 FREIBURG,GERMANY

来源：

SCIENCE | 1993年 / 262卷 / 5131期

关键词：

D O I：

10.1126/science.8211142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus. The presence of both B cells and CD4+ T cells is critical for the development of the disease. Furthermore, a Th2 cytokine response dominates during the progression of the disease. When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice.

引用

页码：240 / 242

页数：3