HONG-KONG STRAINS OF METHICILLIN-RESISTANT AND METHICILLIN-SENSITIVE STAPHYLOCOCCUS-AUREUS HAVE SIMILAR VIRULENCE

被引：109

作者：

FRENCH, GL ^{[1
]}

CHENG, AFB ^{[1
]}

LING, JML ^{[1
]}

MO, P ^{[1
]}

DONNAN, S ^{[1
]}

机构：

[1] CHINESE UNIV HONG KONG,DEPT COMMUNITY MED,SHA TIN,HONG KONG

来源：

JOURNAL OF HOSPITAL INFECTION | 1990年 / 15卷 / 02期

关键词：

bacteraemia; Hong Kong; MRSA; vancomycin; virulence;

D O I：

10.1016/0195-6701(90)90120-D

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

While most authorities agree that methicillin-resistant Staphylococcus aureus (MRSA) are as pathogenic as methicillin-sensitive strains (MSSA), some believe that MRSA are relatively avirulent opportunists, and that their importance has been exaggerated. We present evidence that Hong Kong strains of MRSA and MSSA are equally pathogenic: they have similar virulence in animal models; they are isolated in similar proportions from both deep and superficial clinical sites including blood; in patients with hospital-acquired bacteraemias mortality rates are similar when adjusted for clinical factors; and in both animals and patients with systemic MRSA infection, mortality rates are significantly reduced by vancomycin therapy. Efforts to control the spread of MRSA are justified, and in invasive sepsis early treatment with vancomycin may be life-saving. © 1990.

引用

页码：117 / 125

页数：9