HIGHLY EFFECTIVE PQQ INHIBITION BY ALKYNYL AND ARYL MONOIODONIUM AND DIIODONIUM SALTS

被引：34

作者：

GALLOP, PM ^{[1
]}

PAZ, MA ^{[1
]}

FLUCKIGER, R ^{[1
]}

STANG, PJ ^{[1
]}

ZHDANKIN, VV ^{[1
]}

TYKWINSKI, RR ^{[1
]}

机构：

[1] UNIV UTAH,DEPT CHEM,SALT LAKE CITY,UT 84112

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 25期

关键词：

D O I：

10.1021/ja00078a007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis(iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

引用

收藏

页码：11702 / 11704

页数：3

相关论文

共 44 条

[1]

AIZENMAN E, 1992, J NEUROSCI, V12, P2362

[2]

BARNER N, 1991, J ORG CHEM, V56, P3912

[3] AN ANIMAL-MODEL OF MITOCHONDRIAL MYOPATHY - A BIOCHEMICAL AND PHYSIOLOGICAL INVESTIGATION OF RATS TREATED INVIVO WITH THE NADH-COQ REDUCTASE INHIBITOR, DIPHENYLENEIODONIUM [J].

COOPER, JM ;

PETTY, RKH ;

HAYES, DJ ;

CHALLISS, RAJ ;

BROSNAN, MJ ;

SHOUBRIDGE, EA ;

RADDA, GK ;

MORGANHUGHES, JA ;

CLARK, JB .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1988, 83 (2-3) :335-347

[4] CHRONIC ADMINISTRATION OF THE ORAL HYPOGLYCEMIC AGENT DIPHENYLENEIODONIUM TO RATS - AN ANIMAL-MODEL OF IMPAIRED OXIDATIVE-PHOSPHORYLATION (MITOCHONDRIAL MYOPATHY) [J].

COOPER, JM ;

PETTY, RKH ;

HAYES, DJ ;

MORGANHUGHES, JA ;

CLARK, JB .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (04) :687-694

[5] THE EFFECT OF THE INHIBITOR DIPHENYLENE IODONIUM ON THE SUPEROXIDE-GENERATING SYSTEM OF NEUTROPHILS - SPECIFIC LABELING OF A COMPONENT POLYPEPTIDE OF THE OXIDASE [J].

CROSS, AR ;

JONES, OTG .

BIOCHEMICAL JOURNAL, 1986, 237 (01) :111-116

[6] CHARACTERIZATION OF THE GLYCINE-DEPENDENT REDOXCYCLING ACTIVITY IN ANIMAL FLUIDS AND TISSUES USING SPECIFIC INHIBITORS AND ACTIVATORS - EVIDENCE FOR PRESENCE OF PQQ [J].

FLUCKIGER, R ;

PAZ, M ;

MAH, J ;

BISHOP, A ;

GALLOP, PM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (01) :61-68

[7]

FLUCKIGER R, 1992, PRINCIPLES APPLICATI, P331

[8]

GARDNER G, 1992, SOC NEUROSC, V18

[9]

HAMAGISHI Y, 1990, J PHARMACOL EXP THER, V255, P980

[10] QUINONE DERIVATIVES LOWER BLOOD AND LIVER ACETALDEHYDE BUT NOT ETHANOL CONCENTRATIONS FOLLOWING ETHANOL LOADING TO RATS [J].

HOBARA, N ;

WATANABE, A ;

KOBAYASHI, M ;

TSUJI, T ;

GOMITA, Y ;

ARAKI, Y .

PHARMACOLOGY, 1988, 37 (04) :264-267

← 1 2 3 4 5 →