HIGHLY EFFECTIVE PQQ INHIBITION BY ALKYNYL AND ARYL MONOIODONIUM AND DIIODONIUM SALTS

被引：34

作者：

GALLOP, PM ^{[1
]}

PAZ, MA ^{[1
]}

FLUCKIGER, R ^{[1
]}

STANG, PJ ^{[1
]}

ZHDANKIN, VV ^{[1
]}

TYKWINSKI, RR ^{[1
]}

机构：

[1] UNIV UTAH,DEPT CHEM,SALT LAKE CITY,UT 84112

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 25期

关键词：

D O I：

10.1021/ja00078a007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis(iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

引用

收藏

页码：11702 / 11704

页数：3

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