THE TYROSINE KINASE CONNECTION - HOW GPI-ANCHORED PROTEINS ACTIVATE T-CELLS

被引:210
作者
BROWN, D
机构
[1] State University of New York at Stony Brook, Stony Brook
关键词
D O I
10.1016/0952-7915(93)90052-T
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate T cells when the proteins do not reach the cytosol? Recent results show that glycosylphosphatidylinositol-anchored proteins associate with tyrosine kinases of the src family. Kinase activity is stimulated when glycosylphosphatidylinositol-anchored proteins are crosslinked. How the proteins are linked across the membrane, however, remains an intriguing mystery.
引用
收藏
页码:349 / 354
页数:6
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