THE TYROSINE KINASE CONNECTION - HOW GPI-ANCHORED PROTEINS ACTIVATE T-CELLS

被引：210

作者：

BROWN, D

机构：

[1] State University of New York at Stony Brook, Stony Brook

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 03期

关键词：

D O I：

10.1016/0952-7915(93)90052-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate T cells when the proteins do not reach the cytosol? Recent results show that glycosylphosphatidylinositol-anchored proteins associate with tyrosine kinases of the src family. Kinase activity is stimulated when glycosylphosphatidylinositol-anchored proteins are crosslinked. How the proteins are linked across the membrane, however, remains an intriguing mystery.

引用

收藏

页码：349 / 354

页数：6

相关论文

共 52 条

[31] A GLYCOPHOSPHOLIPID ANCHOR IS REQUIRED FOR QA-2-MEDIATED T-CELL ACTIVATION [J].

ROBINSON, PJ ;

MILLRAIN, M ;

ANTONIOU, J ;

SIMPSON, E ;

MELLOR, AL .

NATURE, 1989, 342 (6245) :85-87

[32] PHOSPHATIDYLINOSITOL MEMBRANE ANCHORS AND T-CELL ACTIVATION [J].

ROBINSON, PJ .

IMMUNOLOGY TODAY, 1991, 12 (01) :35-41

[33]

SAMELSON LE, 1992, J BIOL CHEM, V267, P24913

[34] ASSOCIATION OF THE FYN PROTEIN-TYROSINE KINASE WITH THE T-CELL ANTIGEN RECEPTOR [J].

SAMELSON, LE ;

PHILLIPS, AF ;

LUONG, ET ;

KLAUSNER, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4358-4362

[35]

SANCHO J, 1992, J BIOL CHEM, V267, P7871

[36] PLEIOTROPIC LOSS OF ACTIVATION PATHWAYS IN A T-CELL RECEPTOR ALPHA-CHAIN DELETION VARIANT OF A CYTOLYTIC T-CELL CLONE [J].

SCHMITTVERHULST, AM ;

GUIMEZANES, A ;

BOYER, C ;

POENIE, M ;

TSIEN, R ;

BUFERNE, M ;

HUA, C ;

LESERMAN, L .

NATURE, 1987, 325 (6105) :628-631

[37] SHORT RELATED SEQUENCES IN THE CYTOPLASMIC DOMAINS OF CD4 AND CD8 MEDIATE BINDING TO THE AMINO-TERMINAL DOMAIN OF THE P56LCK TYROSINE PROTEIN-KINASE [J].

SHAW, AS ;

CHALUPNY, J ;

WHITNEY, JA ;

HAMMOND, C ;

AMREIN, KE ;

KAVATHAS, P ;

SEFTON, BM ;

ROSE, JK .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (05) :1853-1862

[38] THE ICK TYROSINE PROTEIN-KINASE INTERACTS WITH THE CYTOPLASMIC TAIL OF THE CD4 GLYCOPROTEIN THROUGH ITS UNIQUE AMINO-TERMINAL DOMAIN [J].

SHAW, AS ;

AMREIN, KE ;

HAMMOND, C ;

STERN, DF ;

SEFTON, BM ;

ROSE, JK .

CELL, 1989, 59 (04) :627-636

[39]

SHENOYSCARIA AM, 1992, J IMMUNOL, V149, P3535

[40] LIPID SORTING IN EPITHELIAL-CELLS [J].

SIMONS, K ;

VAN MEER, G .

BIOCHEMISTRY, 1988, 27 (17) :6197-6202

← 1 2 3 4 5 6 →