Thromboxane modulating agents .1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor thromboxane receptor antagonists

被引：13

作者：

Dickinson, RP

Dack, KN

Steele, J

机构：

[1] Department of Discovery Chemistry, Pfizer Central Research, Sandwich

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 24期

关键词：

D O I：

10.1016/0960-894X(95)00529-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design of a series of dual thromboxane synthase inhibitor/thromboxane receptor antagonists based on an indole thromboxane synthase inhibitor template is described. The indole-5-propanoic acid derivatives 17, 22 and 23 were found to be potent dual agents in vitro.

引用

页码：3017 / 3022

页数：6

共 16 条

[1]

Bhagwat Shripad S., 1994, Drugs of the Future, V19, P765

[2]

COLLINGTON EW, 1990, ANNU REP MED CHEM, V25, P99

[3]

COY JH, 1974, J CHEM SOC P2, P35

[4]

COZZI P, 1991, CURR OPINION THERAPE, P1343