STRUCTURE AND NEURAL MODULATION OF CARDIAC CALCIUM CHANNELS

被引：15

作者：

HARTZELL, HC

DUCHATELLEGOURDON, I

机构：

[1] Department of Cell Biology and Anatomy, Emory University School of Medicine, Atlanta, Georgia

[2] Laboratoire de Physiologie Animale et Bioinformatique, Université de Caen, Caen

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 1992年 / 3卷 / 06期

关键词：

HEART; CALCIUM; IONIC CHANNELS; CALCIUM CHANNELS; DIHYDROPYRIDINES; AUTONOMIC NERVOUS SYSTEM;

D O I：

10.1111/j.1540-8167.1992.tb01937.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The L-type, voltage-gated calcium (Ca) current plays a key role in excitation and initiation of contraction in cardiac muscle cells and is partly responsible for the plateau of the action potential. The ionic channels underlying this current are targets for modulation by the autonomic nervous system. This article reviews recent developments in understanding how these channels are regulated by phosphorylation and G proteins and attempts to relate these findings to recent studies on the molecular structure of the Ca channel.

引用

页码：567 / 578

页数：12

共 114 条

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