MECHANISM-BASED INACTIVATION OF PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM) BY A SUBSTRATE-ANALOG, D-PHENYLALANYL-L-PHENYLALANYL-D-VINYLGLYCINE - INHIBITION OF FORMATION OF PEPTIDE-C-TERMINAL AMIDES

被引：34

作者：

ZABRISKIE, TM ^{[1
]}

CHENG, HM ^{[1
]}

VEDERAS, JC ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 06期

关键词：

D O I：

10.1021/ja00032a058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

收藏

页码：2270 / 2272

页数：3

相关论文

共 27 条

[1] SYNTHESIS OF CHIRAL VINYLGLYCINES
BEAULIEU, PL
DUCEPPE, JS
JOHNSON, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (13) : 4196 - 4204
[2] A RADICAL CLOCK INVESTIGATION OF MICROSOMAL CYTOCHROME-P-450 HYDROXYLATION OF HYDROCARBONS - RATE OF OXYGEN REBOUND
BOWRY, VW
INGOLD, KU
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (15) : 5699 - 5707
[3] 4-PHENYL-3-BUTENOIC ACID, AN INVIVO INHIBITOR OF PEPTIDYLGLYCINE HYDROXYLASE (PEPTIDE AMIDATING ENZYME)
BRADBURY, AF
MISTRY, J
ROOS, BA
SMYTH, DG
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 189 (02): : 363 - 368
[4] BIOSYNTHESIS OF THE C-TERMINAL AMIDE IN PEPTIDE-HORMONES
BRADBURY, AF
SMYTH, DG
[J]. BIOSCIENCE REPORTS, 1987, 7 (12) : 907 - 916
[5] CAPDEVIELLE P, 1991, TETRAHEDRON LETT, V31, P3831
[6] PEPTIDE ALPHA-AMIDATION
EIPPER, BA
MAINS, RE
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1988, 50 : 333 - 344
[7] EIPPER BA, 1991, J BIOL CHEM, V266, P7827
[8] FUJINO M, 1974, CHEM PHARM BULL, V22, P1857
[9] A NOVEL AND EFFICIENT SYNTHESIS OF L-VINYLGLYCINE
HANESSIAN, S
SAHOO, SP
[J]. TETRAHEDRON LETTERS, 1984, 25 (14) : 1425 - 1428
[10] A NOVEL ENZYME FROM BOVINE NEUROINTERMEDIATE PITUITARY CATALYZES DEALKYLATION OF ALPHA-HYDROXYGLYCINE DERIVATIVES, THEREBY FUNCTIONING SEQUENTIALLY WITH PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE IN PEPTIDE AMIDATION
KATOPODIS, AG
PING, DS
MAY, SW
[J]. BIOCHEMISTRY, 1990, 29 (26) : 6115 - 6120