MECHANISM-BASED INACTIVATION OF PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM) BY A SUBSTRATE-ANALOG, D-PHENYLALANYL-L-PHENYLALANYL-D-VINYLGLYCINE - INHIBITION OF FORMATION OF PEPTIDE-C-TERMINAL AMIDES

被引：34

作者：

ZABRISKIE, TM ^{[1
]}

CHENG, HM ^{[1
]}

VEDERAS, JC ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 06期

关键词：

D O I：

10.1021/ja00032a058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

收藏

页码：2270 / 2272

页数：3

相关论文

共 27 条

[21] COPPER-MEDIATED OXIDATIVE C-TERMINAL N-DEALKYLATION OF PEPTIDE-DERIVED LIGANDS - A POSSIBLE MODEL FOR ENZYMATIC GENERATION OF DESGLYCINE PEPTIDE AMIDES
REDDY, KV
JIN, SJ
ARORA, PK
SFEIR, DS
MALONEY, SCF
URBACH, FL
SAYRE, LM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (06) : 2332 - 2340
[22] STEWART LC, 1988, ANNU REV BIOCHEM, V57, P551
[23] ALTERNATIVE MESSENGER-RNA SPLICING GENERATES MULTIPLE FORMS OF PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE IN RAT ATRIUM
STOFFERS, DA
GREEN, CB
EIPPER, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (02) : 735 - 739
[24] TAJIMA M, 1990, J BIOL CHEM, V265, P9602
[25] PEPTIDYLGLYCINE ALPHA-AMIDATING REACTION - EVIDENCE FOR A 2-STEP MECHANISM INVOLVING A STABLE INTERMEDIATE AT NEUTRAL PH
TAKAHASHI, K
OKAMOTO, H
SEINO, H
NOGUCHI, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (02) : 524 - 530
[26] ENZYMATIC PEPTIDYL ALPHA-AMIDATION PROCEEDS THROUGH FORMATION OF AN ALPHA-HYDROXYGLYCINE INTERMEDIATE
YOUNG, SD
TAMBURINI, PP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (05) : 1933 - 1934
[27] INCORPORATION OF AEROBIC OXYGEN INTO THE HYDROXYGLYCYL INTERMEDIATE DURING FORMATION OF C-TERMINAL PEPTIDE AMIDES BY PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE (PAM)
ZABRISKIE, TM
CHENG, HM
VEDERAS, JC
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (08) : 571 - 572