BIOSYNTHESIS OF VITAMIN-B-12 - USE OF SPECIFIC C-13-LABELING FOR STRUCTURAL STUDIES ON FACTOR IV

被引：8

作者：

ALANINE, AID

ICHINOSE, K

THIBAUT, D

DEBUSSCHE, L

STAMFORD, NPJ

LEEPER, FJ

BLANCHE, F

BATTERSBY, AR

机构：

[1] RHONE POULENC RORER,CTR RECH VITRY ALFORTVILLE,DEPT ANAL,F-94403 VITRY,FRANCE

[2] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 02期

关键词：

D O I：

10.1039/c39940000193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[1,10,20-C-13(3)]Uro'gen III is unambiguously synthesised for enzymic conversion into precorrin-4 isolated after aerial oxidation as two epimers of Factor IV, the C-13 NMR spectra of which rigorously confirm the presence of a C-1 acetyl group in precorrin-4; attachment of the fourth methyl group at C-17 of precorrin-4 is also confirmed by related C-13-labelling experiments.

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页码：193 / 196

页数：4

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