MECHANISM OF LITHIUM LETHALITY IN RATS

被引：2

作者：

BERSUDSKY, Y

VINNITSKY, I

GHELBER, D

KOFMAN, O

KAPLAN, Z

BELMAKER, RH

机构：

[1] MINIST HLTH,FAC HLTH SCI,CTR HLTH,IDA & SOLOMON STERN PSYCHIAT RES UNIT,BEER SHEVA,ISRAEL

[2] BEN GURION UNIV NEGEV,DEPT BEHAV SCI,IL-84105 BEER SHEVA,ISRAEL

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1993年 / 27卷 / 04期

关键词：

D O I：

10.1016/0022-3956(93)90068-D

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Lithium inhibits inositol monophosphatase and thereby lowers inositol levels and raises inositol-1-phosphate levels. Many of lithium's biological effects are reversible by inositol replacement. However, lethality caused by high dose lithium was not found to be reversible by intracerebroventricular inositol in various dosages or schedules. Moreover, inositol-1-phosphate, given alone or in the presence of sublethal Li doses to inhibit its degradation, did not show toxic or lethal effects. Therefore inositol depletion or inositol-1-phosphate accumulation are probably not related to lithium lethality.

引用

页码：415 / 422

页数：8

共 25 条

[1] EFFECTS OF LITHIUM ON MYOINOSITOL LEVELS IN LAYERS OF FRONTAL CEREBRAL-CORTEX, IN CEREBELLUM, AND IN CORPUS-CALLOSUM OF THE RAT [J].