PHAGE DISPLAY - PROTEIN ENGINEERING BY DIRECTED EVOLUTION

被引：77

作者：

ONEIL, KT

HOESS, RH

机构：

[1] DuPont Merck Pharmaceutical Company, Chemical and Physical Sciences, Genetics Departments, Wilmington, DE 19880-0328

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0959-440X(95)80027-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phage display of proteins has become an important tool for protein engineering. Over the past year, the versatility of the technology has expanded to include the development of DNA-binding proteins with novel specificities, energetics of protein folding and directed evolution of antibodies. In addition, display of expressed cDNA libraries opens an exciting opportunity for studying protein-protein interactions.

引用

页码：443 / 449

页数：7

共 54 条

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