Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[(2 '-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity

被引：45

作者：

Botta, M

Occhionero, F

Nicoletti, R

Mastromarino, P

Conti, C

Magrini, M

Saladino, R

机构：

[1] Univ Siena, Dipartimento Farm Chim Tecnol, I-53100 Siena, Italy

[2] Univ Rome La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] Univ Rome La Sapienza, Ist Microbiol, Fac Med, I-00185 Rome, Italy

[4] Univ Tuscia, Dipartimento Agrochim Agrobiol, I-01100 Viterbo, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(99)00111-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1925 / 1931

页数：7

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