TOXICITY OF 2-MERCAPTOBENZOTHIAZOLE TOWARDS BACTERIAL-GROWTH AND RESPIRATION

被引：48

作者：

DEWEVER, H ^{[1
]}

DEMOOR, K ^{[1
]}

VERACHTERT, H ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,IND MICROBIOL & BIOCHEM LAB,B-3001 HEVERLEE,BELGIUM

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 1994年 / 42卷 / 04期

关键词：

D O I：

10.1007/BF00173931

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Active sludge systems containing benzothiazoles may be intoxicated by 2-mercaptobenzothiazole (MBT). This toxicity towards several bacteria is now confirmed and is situated at around 100 mg MBT l(-1). Octanol-water partition coefficients indicated that MBT might interact with membrane-bound systems. This was confirmed through experiments showing that bacterial cell respiration was inhibited using lactate or succinate as substrates. Using these substrates and also NADH, it was found that their oxidation was also inhibited using isolated membrane fragments of Escherichia coli and Paracoccus denitrificans. Methylene blue reduction was also found to be inhibited. The oxidation of ascorbate was not inhibited in P. denitrificans. From these results it is suggested that MBT might interact with the respiratory chain at the level of flavoproteins or quinones and Fe-S clusters.

引用

页码：631 / 635

页数：5