SYNTHESIS AND BIOLOGICAL PROPERTIES OF SOME 1-SUBSTITUTED 3-(O-METHOXYPHENOXY)PYRROLIDINES

被引：5

作者：

DUNCAN, RL

HELSLEY, GC

WELSTEAD, WJ

FRANKO, BV

机构：

[1] Research Laboratories, A. H. Robins Company, Inc., Richmond, Virginia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-substituted 3-(o-methoxyphenoxy)pyrrolidines was synthesized and evaluated for pharmacologic activity. The predominant effects of these compounds were a lowering of blood pressure in anesthetized dogs and generalized CNS depression in mice. © 1969, American Chemical Society. All rights reserved.

引用

页码：442 / &

共 6 条

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[3] GROGAN CH, 1965, J MED CHEM, V8, P672
[4] SYNTHESIS AND PHARMACOLOGICAL STUDY OF NEW PIPERAZINE DERIVATIVES .3. PHENOXYALKYLPIPERAZINES
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[5] AROYLALKYLPYRRODLDINES . CENTRAL NERVOUS SYSTEM DEPRESSANTS
WELSTEAD, WJ
HELSLEY, GC
DUNCAN, RL
CALE, AD
TAYLOR, CR
DAVANZO, JP
FRANKO, BV
LUNSFORD, CD
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (03) : 435 - &
[6] AMINOALKYLINDOLES WITH CENTRAL NERVOUS SYSTEM ACTIVITY
WELSTEAD, WJ
DAVANZO, JP
HELSLEY, GC
LUNSFORD, CD
TAYLOR, CR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) : 1015 - &

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