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AROYLALKYLPYRRODLDINES . CENTRAL NERVOUS SYSTEM DEPRESSANTS

被引：15
作者：
WELSTEAD, WJ
HELSLEY, GC
DUNCAN, RL
CALE, AD
TAYLOR, CR
DAVANZO, JP
FRANKO, BV
LUNSFORD, CD
机构：
[1] Research Laboratories, A. H. Robins Company, Inc., Richmond, Virginia
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期
关键词：
D O I：
10.1021/jm00303a023
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The title compounds were prepared by alkylating 3-substituted pyrrolidines with the ketal of γ-chlorobutyrophenones. Several compounds show CNB depressant activity comparable to chlorpromazine. Hypotensive effects were also observed in many of the compounds. © 1969, American Chemical Society. All rights reserved.
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页码：435 / &
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